Clone:
REA445
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Alternative names:
Plxnb2, Debt

Specifications for Plexin-B2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA445 recognizes the mouse Plexin-B2 antigen, a Single-pass type I membrane protein which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T-dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth and cell migration. It has several semaphorin ligands including Semaphorin-3E, Semaphorin-4A, Semaphorin-4C, and Semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with Plexin-B2 on gamma delta T cells to play a role in the healing process.
Additional information: Clone REA445 displays negligible binding to Fc receptors.

Alternative names

Plxnb2, Debt

Detailed product information

Technical specifications

CloneREA445
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenPlexin-B2
Alternative names of antigenPlxnb2, Debt
Molecular mass of antigen [kDa]54
Distribution of antigenastrocytes, T cells, macrophages, dendritic cells
Entrez Gene ID140570
RRIDAB_2653236, AB_2653237, AB_2653238, AB_2653239, AB_2653240, AB_2653241, AB_2653242, AB_2653235

References for Plexin-B2 Antibody, anti-mouse, REAfinity™

Publications

  1. Witherden, D.A. et al. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity 37(2): 314-325
  2. Deng, S. et al. (2007)
    Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system
    in vivo
    .
    J. Neurosci. 27(23): 6333-6347
  3. Saha, B. et al. (2012) Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular Zone. J. Neurosci. 32(47): 16892-16905

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