Clone:
REA341
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, ICFC
Alternative names:
PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2

Specifications for PLC-γ2 pY759 Antibody, anti-human, REAfinity™

Overview

Clone REA341 recognizes the phosphoinositide phospholipase C-gamma-2 (PLC-γ2) antigen phosphorylated at tyrosine 759 (pY759). PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell antigen receptors) that are linked to the activation of nonreceptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Phosphorylation of PLC-γ2 at tyrosines 753 and 759 leads to activation of the enzyme. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells.
Additional information: Clone REA341 displays negligible binding to Fc receptors.

Alternative names

PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2

Detailed product information

Technical specifications

CloneREA341
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPLC-γ2 pY759
Alternative names of antigenPLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
Molecular mass of antigen [kDa]148
Distribution of antigenstem cells, hematopoietic stem and progenitor cells
Entrez Gene ID5336
RRIDAB_2653223, AB_2653224, AB_2653225, AB_2653226, AB_2653227, AB_2653228

References for PLC-γ2 pY759 Antibody, anti-human, REAfinity™

Publications

  1. Ombrello, M. J. et al. (2012) Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions N. Engl. J. Med. 366(4): 330-338
  2. Rodriguez, R. et al. (2001) Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling J. Biol. Chem. 276(51): 47982-47992
  3. Ozdener, F. et al. (2002) Activation of phospholipase Cgamma2 by tyrosine phosphorylation Mol. Pharmacol. 62(3): 672-679

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