Clone:
REA790
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
MEGF12

Specifications for PEAR1 Antibody, anti-human, REAfinity™

Overview

Clone REA790 recognizes the human platelet endothelial aggregation receptor 1 (PEAR1) antigen, a type I transmembrane protein also known as MEGF12. PEAR1, an EGF-containing receptor and member of the MEGF family, is found in various tissues. High levels of PEAR1 are found in platelets and endothelial cells, it is weakly expressed in peripheral blood leukocytes and macrophages. PEAR1 becomes activated by platelet contact and is involved in agonist-induced platelet aggregation.
Additional information: Clone REA790 displays negligible binding to Fc receptors.

Alternative names

MEGF12

Detailed product information

Technical specifications

CloneREA790
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPEAR1
Alternative names of antigenMEGF12
Distribution of antigenendothelial cells, megakaryocytes, osteoblasts, macrophages, leukocytes, brain, breast, heart, kidney, lung, ovary, pancreas, skeletal muscle
RRIDAB_2653172, AB_2653173, AB_2653174, AB_2653175, AB_2653176, AB_2653177, AB_2653178, AB_2653171

References for PEAR1 Antibody, anti-human, REAfinity™

Publications

  1. Nanda, N. et al. (2005) Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J. Biol. Chem. 280(26): 24680-24689
  2. Nanda, N. et al. (2006) Novel targets for antithrombotic drug discovery. Blood Cells Mol. Dis. 36(2): 228-231
  3. Herrera-Galeano, J. E. et al. (2008) A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. Arterioscler. Thromb. Vasc. Biol. 28(8): 1484-1490

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