Clone:
REA843
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
IF, IHC
Alternative names:
S6K-beta-1, S6K1, P70S6K1, p70-S6K 1

Specifications for p70 S6 Kinase Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA843 recognizes the intracellular p70 S6 Kinase, also known as ribosomal protein S6 kinase beta-1. It is a serine/threonine kinase that is widely expressed in the cytosol and in the nucleus. It mediates cell cycle progression and is involved in the regulation of protein synthesis. The p70 S6 kinase is localized in cytosol and in the nucleus, after cytokine stimulation. TNF-receptor activation leads to activation of the p70 S6 kinase, which increases protein synthesis and cell proliferation. In addition, p70 S6 kinase is a major effector of mammalian target of rapamycin (mTOR) phosphorylation.
Additional information: Clone REA843 displays negligible binding to Fc receptors.

Alternative names

S6K-beta-1, S6K1, P70S6K1, p70-S6K 1

Detailed product information

Technical specifications

CloneREA843
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
Antigenp70 S6 Kinase
Alternative names of antigenS6K-beta-1, S6K1, P70S6K1, p70-S6K 1
Molecular mass of antigen [kDa]59(same molecular weight for human and mouse/rat)
Distribution of antigenubiquitous
Entrez Gene ID6198, 72508, 83840
RRIDAB_2653147, AB_2653148, AB_2653149, AB_2653150, AB_2653151, AB_2653152, AB_2653153, AB_2653146

References for p70 S6 Kinase Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Gout, I. et al. (1998) Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. J. Biol. Chem. 273(46): 30061-30064
  2. Fleckenstein, D. S. et al. (2003) Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. Leuk. Res. 27(8): 687-694
  3. Holz, M. K. et al. (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280(28): 26089-26093

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