Clone:
REA609
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
BCC7, LFS1, P53, TRP53

Specifications for p53 Antibody, anti-human, REAfinity™

Overview

Clone REA609 recognizes the human cellular tumor antigen p53. The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death.
Additional information: Clone REA609 displays negligible binding to Fc receptors.

Alternative names

BCC7, LFS1, P53, TRP53

Detailed product information

Technical specifications

CloneREA609
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
Cross-reactivitymouse, rat
Antigenp53
Alternative names of antigenBCC7, LFS1, P53, TRP53
Molecular mass of antigen [kDa]44
Distribution of antigenother
Entrez Gene ID7157
RRIDAB_2653136, AB_2653137

References for p53 Antibody, anti-human, REAfinity™

Publications

  1. Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4(5): 1251-1255
  2. Lamb, P. et al. (1986) Characterization of the human p53 gene. Mol. Cell. Biol. 6(5): 1379-1385
  3. Stiewe, T. (2007) The p53 family in differentiation and tumorigenesis. Nat. Rev. Cancer 7(3): 165-168

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