Clone:
REA548
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Specifications for p120 Catenin pS879 Antibody, anti-human, REAfinity™

Overview

Clone REA548 recognizes the S879-phosphorylated form of p120 catenin, a prototypic member of the subfamily of armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and non-classical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Furthermore, lack of p120 catenin in mouse leads to tumor development, suggesting its further role as tumor supressor. Phosphorylation of p120 catenin at multiple sites regulates its various functions and can be phosphorylated by Src and various receptor tyrosine kinases.
Additional information: Clone REA548 displays negligible binding to Fc receptors.

Alternative names

CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Detailed product information

Technical specifications

CloneREA548
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Antigenp120 Catenin pS879
Alternative names of antigenCTNND1, CAS, CTNND, p120cas, p120ctn, p120
Molecular mass of antigen [kDa]108
Distribution of antigentumor cells
Entrez Gene ID1500
RRIDAB_2653110, AB_2653111

References for p120 Catenin pS879 Antibody, anti-human, REAfinity™

Publications

  1. Stairs, D. B. et al. (2011) Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell 19(4): 470-483
  2. Vandenbroucke St Amand, E. et al. (2012) PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity. Circ. Res. 111(6): 739-749
  3. Reynolds, A. B. et al. (2004) Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene 23(48): 7947-7956

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