Clone:
REA837
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
OSMRb, IL-31RB

Specifications for OSMRβ Antibody, anti-human, REAfinity™

Overview

Clone REA837 recognizes the human Anti-OSMRβ antigen, the β subunit of the Oncostatin-M-specific receptor (OSMR). OSMRβ belongs to the IL-6 receptor family and is activated by Oncostatin-M. Its expression is up-regulated by IFN-γ and bacterial lipopolysaccharides (LPS). OSMRβ is found in high levels in all neural cells as well as in fibroblast, in epithelial cells, and in a variety of tumor cell lines. OSM is most closely related to leukemia inhibitory factor (LIF) and it utilizes the LIF receptor in addition to its specific receptor in the human.
Additional information: Clone REA837 displays negligible binding to Fc receptors.

Alternative names

OSMRb, IL-31RB

Detailed product information

Technical specifications

CloneREA837
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenOSMRβ
Alternative names of antigenOSMRb, IL-31RB
Molecular mass of antigen [kDa]107
Distribution of antigenepithelial cells, fibroblasts
Entrez Gene ID9180
RRIDAB_2653097, AB_2653098, AB_2653099, AB_2653100, AB_2653101, AB_2653096

References for OSMRβ Antibody, anti-human, REAfinity™

Publications

  1. Mosley, B. et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271(51): 32635-32643
  2. Tanaka, M. and Miyajima, A. (2003) Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. 149: 39-52

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