Clone:
REA494
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
PIgR3, PIgR-3, hOSCAR

Extended validation for OSCAR Antibody, anti-human, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA494
11.1CN5++
5B8-
Cells were incubated with an excess of purified unconjugated OSCAR (REA494) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for OSCAR Antibody, anti-human, REAfinity™

Overview

Clone REA494 recognizes the human osteoclast-associated immunoglobulin-like receptor (OSCAR) antigen, a 45 kDa single-pass type I membrane protein also known as polymeric immunoglobulin receptor 3 (PIgR-3). OSCAR is a member of the leukocyte receptor complex (LRC) protein family and is an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. OSCAR expression is detected in preosteoclasts or mature osteoclasts. Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. These cells originate from hematopoietic precursors and share a common progenitor with macrophages and dendritic cells. Human OSCAR is also expressed at all stages of myeloid dendritic cell maturation, on
in vitro
derived macrophages, granulocytes, and monocyte derived dendritic cells.
Additional information: Clone REA494 displays negligible binding to Fc receptors.

Alternative names

PIgR3, PIgR-3, hOSCAR

Detailed product information

Technical specifications

CloneREA494
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenOSCAR
Alternative names of antigenPIgR3, PIgR-3, hOSCAR
Molecular mass of antigen [kDa]28
Distribution of antigendendritic cells, macrophages, osteoclasts
Entrez Gene ID126014
RRIDAB_2751733, AB_2653088, AB_2653089, AB_2653090, AB_2653091, AB_2653094, AB_2653095, AB_2751793

Resources for OSCAR Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for OSCAR Antibody, anti-human, REAfinity™

Publications

  1. Barrow, A. D. et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121(9): 3505-3516
  2. Kim, N. et al. (2002) A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J. Exp. Med. 195(2): 201-209
  3. Goettsch, C. et al. (2011) The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology 152(12): 4915-4926

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