Clone:
O4
Type of antibody:
Primary antibodies
Isotype:
mouse IgM
Applications:
FC, MICS, IF, IHC

Specifications for O4 Antibody, anti-human/mouse/rat

Overview

During oligodendrocyte development, late A2B5
+
oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. In the peripheral nervous system, O4 expression is found on Schwann cells.

Detailed product information

Technical specifications

CloneO4
Clonalitymonoclonal
Isotypemouse IgM
Isotype controlIsotype Control Antibody, mouse IgM
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, mouse, rat
AntigenO4
RRIDAB_2733887, AB_2751644, AB_2751598, AB_2751959, AB_2751912, AB_2727204, AB_2733886

Resources for O4 Antibody, anti-human/mouse/rat

References for O4 Antibody, anti-human/mouse/rat

Publications

  1. Jungblut, M. et al. (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60(6): 894-907
  2. G. Kantzer, C. et al. (2017) Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia 65(6): 990-1004
  3. Zhang, S.C. (2001) Defining glial cells during CNS development. Nat. Rev. Neurosci. 2: 840-843
  4. Sommer, I. and Schachner, M. (1981) Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev. Biol. 83: 311-327
  5. Bansal, R. et al. (1989) Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development. J. Neurosci. Res. 24(4): 548-557

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