Clone:
HMN2-35
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC
Alternative names:
N2

Specifications for Notch2 Antibody, anti-mouse

Overview

Clone HMN2-35 recognizes Notch2, a member of the Notch receptor family. Notch2 acts as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1. Notch signaling pathway is evolutionary conserved in the animal kingdom, where Notch receptors upon ligand binding undergo two proteolytic cleavages. The second cleavage releases the Notch intracellular domain (NICD), which translocates into the nucleus, forms an activator complex with the DNA binding protein RBP-J and activates genes of the enhancer of split locus. Notch signaling network regulates a number of biological processes involved in determination of cell fate, cell differentiation and apoptosis etc.

Alternative names

N2

Detailed product information

Technical specifications

CloneHMN2-35
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenNotch2
Alternative names of antigenN2
Molecular mass of antigen [kDa]263
Entrez Gene ID18129
RRIDAB_2653054, AB_2653055, AB_2653056, AB_2653057, AB_2653058, AB_2653053

References for Notch2 Antibody, anti-mouse

Publications

  1. Maekawa, Y. et al. (2008) Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat. Immunol. 9(10): 1140-1147
  2. Borggrefe, T. et al. (2009 ) The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell. Mol. Life Sci. 66(10): 1631-1646

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