Clone:
MHN2-25
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC
Alternative names:
AGS2, HJCYS, hN2

Specifications for Notch2 Antibody, anti-human

Overview

The MHN2-25 mononuclear antibody reats with the extracellular domain of human Notch2, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multiprotein complex. Notch2 is expressed on various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. In addition, the altered expression of Notch2 in various leukemias, lymphomas, and cancers has been reported.

Alternative names

AGS2, HJCYS, hN2

Detailed product information

Technical specifications

CloneMHN2-25
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenNotch2
Alternative names of antigenAGS2, HJCYS, hN2
Molecular mass of antigen [kDa]263
Entrez Gene ID4853
RRIDAB_2653060, AB_2653061, AB_2653059

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Notch2 Antibody, anti-human

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