Clone:
REA849
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Notch 1, TAN-1, Motch A, mT14, p300, hN1

Specifications for Notch1 Antibody, anti-human, REAfinity™

Overview

Clone REA849 recognizes the human neurogenic locus notch homolog protein 1 (Notch1) antigen, a 300 kDa single-pass type I membrane protein also known as translocation-associated notch protein (TAN-1). Following cleavage in the Golgi, notch forms a heterodimer composed of a 180–200 kDa disulfide-linked extracellular domain (Notch extracellular truncation (NEXT)), and a 120 kDa membrane-bound intracellular portion (Notch intracellular domain (NICD)). Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, Notch1 plays a non-redundant role for thymic T cell development. Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation and also found on bone marrow hematopoietic stem cells, NK cells, B cells, and monocytes .
Additional information: Clone REA849 displays negligible binding to Fc receptors.

Alternative names

Notch 1, TAN-1, Motch A, mT14, p300, hN1

Detailed product information

Technical specifications

CloneREA849
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenNotch1
Alternative names of antigenNotch 1, TAN-1, Motch A, mT14, p300, hN1
Molecular mass of antigen [kDa]269
Distribution of antigenNK cells, T cells, B cells, stem cells, monocytes, bone marrow
Entrez Gene ID18128
RRIDAB_2653042, AB_2653043, AB_2653044, AB_2653045, AB_2653046, AB_2653047, AB_2653048, AB_2653049

References for Notch1 Antibody, anti-human, REAfinity™

Publications

  1. Gray, G. E. et al. (1999) Human ligands of the Notch receptor. Am. J. Pathol. 154(3): 785-794
  2. Weng, A. P. et al. (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306(5694): 269-271
  3. Arruga, F. et al. (2014) Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia 28(5): 1060-1070

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