Clone:
REA845
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
KLRF1, CLEC5C

Specifications for NKp80 Antibody, anti-human, REAfinity™

Overview

Clone REA845 recognizes the human NKp80 antigen, an 80 kDa homodimeric surface molecule belonging to the family of C-type lectin-like receptors. NKp80 is expressed on all human natural killer (NK) cells and on a small subset of effector memory CD8
+
T cells. NKp80 stimulates NK cell cytotoxicity and cytokine release and appears to co-operate with other triggering receptors to induce optimal NK cell activation upon interaction with potential target cells. The ligand of NKp80 is activation-induced C-type lectin (AICL), also called CLEC2B.
Additional information: Clone REA845 displays negligible binding to Fc receptors.

Alternative names

KLRF1, CLEC5C

Detailed product information

Technical specifications

CloneREA845
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
,
rhesus monkey (
Macaca mulatta
)
AntigenNKp80
Alternative names of antigenKLRF1, CLEC5C
Distribution of antigenNK cells, T cells
Entrez Gene ID51348
RRIDAB_2653020, AB_2653021, AB_2653022, AB_2653023, AB_2653024, AB_2653025, AB_2653026, AB_2653027, AB_2653028, AB_2653029, AB_2653030, AB_2653031, AB_2751105, AB_2751104, AB_2653032, AB_2653033, AB_2653019

References for NKp80 Antibody, anti-human, REAfinity™

Publications

  1. Kuttruff, S. et al. (2009) NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood 113: 358-369
  2. Welte, S. et al. (2006) Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction. Nat. Immunol. 7: 1334-1342
  3. Vitale, M. et al. (2001) Identification of NKp80, a novel triggering molecule expressed by human NK cells. Eur. J. Immunol. 31: 233-242

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