Clone:
REA1100
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CD159a, CD159c, CD159e, NKG2A, KLRC1, NKG2C1, KLRC2, NKG2E, KLRC3

Specifications for NKG2A/C/E Antibody, anti-mouse, REAfinity™

Overview

Clone REA1100 recognizes the mouse NKG2A, NKG2C, and NKG2E antigen on a subset of natural killer (NK) and NK-T cells in most mouse strains, for example, AKR/J, BALB/c, C3H/He,C57BL/6, CBA/J, DBA/1, FVB/N, 129/Sv, NOD, SWR, and most DBA/2 substrains, but not DBA/2J. The C-type lectin-like NKG2 receptors form heterodimers of CD94 and one of several NKG2 family members, i.e., NKG2A (CD159a), NKG2C (CD159c), or NKG2E. CD94/NKG2 receptors monitor classical class I expression indirectly by means of the recognition of classical class I signal peptides. These signal peptides are processed to a nonameric peptide called Qdm that is presented to CD94/NKG2
+
NK cells by a non-classical MHC class I molecule called Qa-1. CD94/NKG2 receptors equip NK cells with the capacity to detect cells with abnormal MHC class I expression, such as often results from viral infection or transformation.
Additional information: Clone REA1100 displays negligible binding to Fc receptors.

Alternative names

CD159a, CD159c, CD159e, NKG2A, KLRC1, NKG2C1, KLRC2, NKG2E, KLRC3

Detailed product information

Technical specifications

CloneREA1100
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenNKG2A/C/E
Alternative names of antigenCD159a, CD159c, CD159e, NKG2A, KLRC1, NKG2C1, KLRC2, NKG2E, KLRC3
Molecular mass of antigen [kDa]28
Distribution of antigenNK cells, NKT cells
Entrez Gene ID16641
RRIDAB_2733884, AB_2733885, AB_2733443, AB_2733009, AB_2733010, AB_2733278, AB_2733165, AB_2734049, AB_2734050

References for NKG2A/C/E Antibody, anti-mouse, REAfinity™

Publications

  1. Lohwasser, S. et al. (1999) Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Eur. J. Immunol. 29(3): 755-761
  2. Silver, E. T. et al. (1999) Molecular cloning of mouse NKG2A and C. Immunogenetics 49(7-8): 727-730
  3. Foley, B. et al. (2012)
    Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C
    +
    natural killer cells with potent function.
    Blood 119(11): 2665-2674

Seems like you are coming from USA!
Do you want to visit our website in your country?