Clone:
REA348
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, ICFC, MICS, IF, IHC
Alternative names:
NFKB1, EBP-1, KBF1, NF-kB1, NFKB-p105, NFKB-p50, p105, p50, NF-kB

Specifications for NF-κB p65 pS529 Antibody, anti-human, REAfinity™

Overview

Clone REA348 recognizes the human NF-κB p65 antigen phosphorylated at serine 529 (pS529). NF-κB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis. It is a homo- or heterodimeric complex and the heterodimeric p65-p50 complex is the most abundant one. Optimal induction of NF-κB target genes also requires phosphorylation of NF-κB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli.
Additional information: Clone REA348 displays negligible binding to Fc receptors.

Alternative names

NFKB1, EBP-1, KBF1, NF-kB1, NFKB-p105, NFKB-p50, p105, p50, NF-kB

Detailed product information

Technical specifications

CloneREA348
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenNF-κB p65 pS529
Alternative names of antigenNFKB1, EBP-1, KBF1, NF-kB1, NFKB-p105, NFKB-p50, p105, p50, NF-kB
Molecular mass of antigen [kDa]60(average of subunits)
Distribution of antigenother
Entrez Gene ID5970

References for NF-κB p65 pS529 Antibody, anti-human, REAfinity™

Publications

  1. Oeckinghaus, A. et al. (2011) Crosstalk in NF-κB signaling pathways Nat. Immunol. 12(8): 695-708
  2. Ruben, S. M. et al. (1991) Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-κ B. Science 251(5000): 1490-1493
  3. Viatour, P. et al. (2005) Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation Trends Biochem. Sci. 30(1): 43-52

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