Clone:
REA575
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
NES, ESTM46

Specifications for Nestin Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA575 recognizes the mouse and rat nestin antigen, a type VI intermediate filament protein, mainly expressed in the developing central nervous system and skeletal muscles. In adult eye, nestin is present in the optic nerve but also transiently expressed in the midembryonic mouse heart. Nestin plays a role in regulation of the assembly and disassembly of phosphorylated vimentin intermediate filaments during mitosis. It is involved in the trafficking and distribution of intermediate filament (IF) proteins and other cellular factors to daughter cells during progenitor cell division.
Additional information: Clone REA575 displays negligible binding to Fc receptors.

Alternative names

NES, ESTM46

Detailed product information

Technical specifications

CloneREA575
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, rat
AntigenNestin
Alternative names of antigenNES, ESTM46
Molecular mass of antigen [kDa]207, 209(separately shown for mouse and rat)
Distribution of antigenstem cells, neural stem cells
Entrez Gene ID18008, 25491
RRIDAB_2752025, AB_2751852

References for Nestin Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Kachinsky, A. M. et al. (1995) Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart. J. Histochem. Cytochem. 43(8): 843-847
  2. Park, D. et al. (2010) Nestin is required for the proper self-renewal of neural stem cells. Stem Cells 28(12): 2162-2171
  3. Yang, J. et al. (2000) Nestin expression during mouse eye and lens development. Mech. Dev. 94(1-2): 287-291

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Nestin Antibody, anti-mouse/rat, REAfinity™

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