Clone:
REA1107
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
SM-MHC

Specifications for Myosin Smooth Muscle Antibody, anti-human, REAfinity™

Overview

Clone REA1107 recognizes both isoforms of the Myosin Smooth Muscle heavy chain (MHC-1 and MHC-2). Myosin Smooth Muscle is cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. REA1107 recognizes visceral and vascular smooth muscle cells, but also myoepithelial cells. It is a marker for distingushing between benign sclerosing breast lesions (positive) and infiltrating carcinomas (negative).
Additional information: Clone REA1107 displays negligible binding to Fc receptors.

Alternative names

SM-MHC

Detailed product information

Technical specifications

CloneREA1107
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenMyosin Smooth Muscle
Alternative names of antigenSM-MHC
Molecular mass of antigen [kDa]227
Distribution of antigensmooth muscle
Entrez Gene ID4629
RRIDAB_2857441, AB_2857442, AB_2857440

References for Myosin Smooth Muscle Antibody, anti-human, REAfinity™

Publications

  1. Lazard, D. et al. (1993) Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc. Natl. Acad. Sci. U.S.A. 90(3): 999-1003
  2. Wang, N. P. et al. (1997) Antibodies to novel myoepithelium-associated proteins distinguish benign lesions and in-situ- carcinoma from invasive carcinoma of the breast. Appl. Immunohistochem. 5(3): 141-151