Clone:
REA1076
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
MICB, PERB11.2, MICA, PERB11.1

Specifications for MICA/MICB Antibody, anti-human, REAfinity™

Overview

Clone REA1076 recognizes MICA and MICB, which are transmembrane glycoproteins related to major histocompatibility complex (MHC) class I molecules. In contrast to other MHC class I proteins, MICA and MICB have no association with β2-microglobulin and do not bind peptides. They are ligands for NKG2D, which is expressed on NK cells and many T cells. MICA and MICB are expressed on endothelial cells and fibroblasts and are stress-induced in epithelial cells.
Additional information: Clone REA1076 displays negligible binding to Fc receptors.

Alternative names

MICB, PERB11.2, MICA, PERB11.1

Detailed product information

Technical specifications

CloneREA1076
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenMICA/MICB
Alternative names of antigenMICB, PERB11.2, MICA, PERB11.1
Molecular mass of antigen [kDa]41
Distribution of antigenendothelial cells, epithelial cells, fibroblasts, NK cells, T cells
Entrez Gene ID100507436, 4277
RRIDAB_2733878, AB_2733879, AB_2733437, AB_2733438, AB_2733006, AB_2733007, AB_2733272, AB_2733273, AB_2733061, AB_2733062, AB_2734045, AB_2734046, AB_2733560, AB_2733561

References for MICA/MICB Antibody, anti-human, REAfinity™

Publications

  1. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
  2. Bauer, S. et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729
  3. Li, P. et al. (1999) Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand. Immunity 10: 577-584

Related products for
MICA/MICB Antibody, anti-human, REAfinity™

3 products available