Clone:
REA510
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
RT1D

Specifications for MHC Class II (I-Ek) Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA510 recognizes the mouse MHC class II alloantigen I-Ek. It also recognizes the rat MHC class II antigen RT1D and cells from mice of the H-2
d
, H-2
p
, and H-2
r
haplotypes. Cells from mice of the H-2
b
, H-2
f
, H-2
g7
, H-2
q
, and H-2
s
haplotypes do not express the I-E antigen. MHC class II is expressed on antigen-presenting cells, such as dendritic cells, monocytes, macrophages, B cells in lymphoid and non-lymphoid tissue, thymic epithelial cells, and on subsets of hematopoietic progenitor cells in the bone marrow.
Additional information: Clone REA510 displays negligible binding to Fc receptors.

Alternative names

RT1D

Detailed product information

Technical specifications

CloneREA510
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, rat
AntigenMHC Class II (I-Ek)
Alternative names of antigenRT1D
Molecular mass of antigen [kDa]27(same molecular weight for human and mouse/rat)
Distribution of antigenB cells, dendritic cells, macrophages, monocytes, epithelial cells, hematopoietic stem and progenitor cells
Entrez Gene ID14969, 294270
RRIDAB_2652883, AB_2652884, AB_2652885, AB_2652886, AB_2652887, AB_2652888, AB_2652889, AB_2652890, AB_2652891, AB_2652892, AB_2652893, AB_2652894, AB_2652895, AB_2652896, AB_2652897, AB_2652898, AB_2652899, AB_2652900, AB_2652901, AB_2652882

References for MHC Class II (I-Ek) Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Yelon, D. et al. (1999)
    Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4
    +
    T cell development.
    J. Immunol. 162(3): 1348-1358
  2. Vestberg, M. et al. (1998) Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule. Immunogenetics 48(5): 344-349
  3. Kasson, P. M. et al. (2000) Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry 39(5): 1048-1058

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