Clone:
REAL639
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
MT

Specifications for Metallothionein Antibody, anti-human, REAdye_lease™

Overview

Clone REAL639 is an antibody fragment derived from the full Anti-Metallothionein antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL639 recognizes the human Metallothionein, a cytoplasmatic protein, which has a high content of cysteine and no aromatic amino acids. Metallothionein is able to bind and sequestrate heavy metal ions and is transcriptionally regulated by heavy metals, glucocorticoids, interferon, lymphokines and stress. The isoforms of Metallothionein MT I and MT II have the ability to scavenge free radicals and play a role in carcinogenesis. Overexpression is found in cancers, e.g. different carcinomas and melanoma.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

MT

Detailed product information

Technical specifications

CloneREAL639
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenMetallothionein
Alternative names of antigenMT
Distribution of antigentumor cells, melanoma, kidney

References for Metallothionein Antibody, anti-human, REAdye_lease™

Publications

  1. Kägi, J.H. et al. (1974) Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content. J. Biol. Chem. 249(11): 3537-3542
  2. Kumari, M. V. et al. (1998) Free radical scavenging actions of metallothionein isoforms I and II. Free Radic. Res. 29(2): 93-101
  3. Tuccari, G. et al. (2000) Immunohistochemical detection of metallothionein in carcinomatous and normal human gastric mucosa. Histol. Histopathol. 15(4): 1035-1041

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