Clone:
REA449
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
MAP2K2, CFC4, MAPKK 2, MKK2, PRKMK2, MEK 2, MAPK/ERK kinase 2

Specifications for MEK2 Antibody, anti-human, REAfinity™

Overview

Clone REA449 recognizes the human MEK2 antigen regardless of phosphorylation status. MEK2 is a serine/threonine kinase also known as MAP kinase kinase (MAPKK 2) or MAPK/ERK kinase 2. The dual specificity kinases MEK1 and MEK2 are activated by RAF and mediate phosphorylation of ERK1 and ERK2. MEK1 and MEK2 are very similar but differ structurally in a proline-rich domain in the C-terminal half of the catalytic core. Binding of extracellular ligands such as growth factors, cytokines, and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival, and differentiation, predominantly through the regulation of transcription, metabolism, and cytoskeletal rearrangements.
Additional information: Clone REA449 displays negligible binding to Fc receptors.

Alternative names

MAP2K2, CFC4, MAPKK 2, MKK2, PRKMK2, MEK 2, MAPK/ERK kinase 2

Detailed product information

Technical specifications

CloneREA449
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitymouse, rat, dog, chicken, frog
AntigenMEK2
Alternative names of antigenMAP2K2, CFC4, MAPKK 2, MKK2, PRKMK2, MEK 2, MAPK/ERK kinase 2
Molecular mass of antigen [kDa]44
Entrez Gene ID5605
RRIDAB_2652849, AB_2652850, AB_2652851, AB_2652848

References for MEK2 Antibody, anti-human, REAfinity™

Publications

  1. Zheng, C. F. et al. (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268(15): 11435-11439
  2. Kocieniewski, P. et al. (2013) MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response. Phys. Biol. 10(3): 035006-035006
  3. Ohren, J. F. et al. (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat. Struct. Mol. Biol. 11(12): 1192-1197

Related products for
MEK2 Antibody, anti-human, REAfinity™

3 products available