Clone:
REA155
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1

Specifications for MEK1 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA155 recognizes MEK1, a 45 KDa serine/threonine kinase and a component of the MAPK signal transduction cascade. In response to ligands such as growth factors, cytokines, and hormones, respective cell surface receptors are engaged and activate GTP-bound Ras, which transmits the signal by activating the protein kinases Raf-1, B-Raf, and A-Raf (Rafs), the MAP3K components of the cascade. MEK1 and the related kinase MEK2 are then the targets of MAP3K and transmit the signal further by phosphorylating the MAP kinases ERK1/ERK2. MAPK signal transduction pathway is involved in large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription.
Additional information: Clone REA155 displays negligible binding to Fc receptors.

Alternative names

MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1

Detailed product information

Technical specifications

CloneREA155
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenMEK1
Alternative names of antigenMAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1
Molecular mass of antigen [kDa]43
Entrez Gene ID5604
RRIDAB_2652841, AB_2652842, AB_2652843, AB_2652840

References for MEK1 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Roskoski, R. et al. (2012) MEK1/2 dual-specificity protein kinases: structure and regulation. Biochem. Biophys. Res. Commun. 417(1): 5-10
  2. Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42(4): 459-467

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MEK1 Antibody, anti-human/mouse, REAfinity™

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