Background information
Interleukin 12 (IL-12) is a heterodimeric proinflammatory cytokine and a modulator of cell-mediated immunity, which is mainly produced by macrophages, dendritic cells, and B cells.
IL-12 stimulates the production and secretion of several cytokines, in particular IFN-γ, by NK cells and T cells, induces proliferation, and enhances the cytotoxic activity within these cell populations.
Another important activity of IL-12, acting together with IFN-γ and IL-2, is to drive T helper cell responses toward the T
H1 rather than the T
H2 phenotype. Moreover, IL-12 is also important in resistance to viral disease and has significant antitumor activity.
It has been shown that single chain fusion proteins of naturally occurring heterodimeric cytokines such as IL-12 or IL-23 are bioactive
in vitro and in
vivo.
2-4Applications
Human IL-12 can be used for a variety of applications, including:
- In vitro differentiation of naive CD4+ T cells towards TH1 cells.
- In vitro proliferation and stimulation of cytotoxic activity of NK cells and T cells
Quality statement
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
User
Favorite list
