The content of MACS GMP Rapamycin is sufficient to result in a 100 nM ready-to-use Treg expansion medium in combination with TexMACS™ GMP Medium (2000 mL).

Specifications for
MACS
®
GMP Rapamycin

Overview

The content of MACS GMP Rapamycin is sufficient to result in a 100 nM ready-to-use Treg expansion medium in combination with TexMACS™ GMP Medium (2000 mL).

Detailed product information

Background information

MACS GMP Rapamycin is sufficient for the supplementation of 2000 mL TexMACS GMP Medium and used in expansion protocols for regulatory T cells (Treg cells). Rapamycin inhibits the expansion of conventional T cells and thereby enhances the proportion of expanded Treg cells in culture.
1

Applications

The manufacturing of a large number of Treg cells for clinical research can be achieved with the use of the MACS GMP ExpAct Treg Kit, TexMACS GMP Medium supplemented with MACS GMP Rapamycin and the CliniMACS CD25 enrichment procedure.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Resources for
MACS
®
GMP Rapamycin

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for
MACS
®
GMP Rapamycin

Publications

  1. Battaglia, M. et al. (2005)
    Rapamycin selectively expands CD4
    +
    CD25
    +
    FoxP3
    +
    regulatory T cells.
    Blood 105: 4743-4748

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