MACS GMP PepTivator EBV Select is a peptide pool that consists of 43 lyophilized MHC class I and class II restricted peptides derived from 15 different proteins from Epstein-Barr virus (EBV). It has been developed for efficient
in vitro
stimulation and subsequent isolation of EBV–specific CD4
+
and CD8
+
T cells.

Specifications for
MACS
®
GMP PepTivator
®
EBV Select

Overview

MACS GMP PepTivator EBV Select is a peptide pool that consists of 43 lyophilized MHC class I and class II restricted peptides derived from 15 different proteins from Epstein-Barr virus (EBV). It has been developed for efficient
in vitro
stimulation and subsequent isolation of EBV–specific CD4
+
and CD8
+
T cells.

Detailed product information

Background information

Epstein-Barr virus (EBV) is a human γ-herpesvirus with B cell growth–transforming ability and carcinogenic potential. More than 90% of human adults are infected with EBV. In healthy individuals, EBV typically establishes a persistent latent infection, in which the virus can be detected in resting, non-proliferating peripheral B lymphocytes.
MACS GMP PepTivator EBV Select is a peptide pool that consists of 43 lyophilized MHC class I and class II restricted peptides derived from 15 different proteins from Epstein-Barr virus (EBV): LMP2a; BRLF1; BMLF1 (EB2); BNLF1 (LMP1); BERF3 (EBNA6); BERF1 (EBNA3); BERF2 (EBNA4); BALF2 (DNBI); BMRF1; BZLF1; BNRF1 (MTP); EBNA1; BLLF1 (gp350); BXLF2; EBNA2. The peptides are restricted for the following HLA-molecules: HLA-A*02, -A*03, -A*ll, -A*24, -A*26, -B*07, -B*08, -B*15, -B*18, -B*27, -B*35, -B*40, -B*4402, -DR.

Applications

MACS GMP PepTivator EBV Select can be used for a variety of applications, for example,
in vitro
stimulation of EBV-specific CD4
+
and CD8
+
T cells for the enrichment of IFN-gamma–secreting T cells using the CliniMACS
®
Cytokine Capture System (IFN-gamma) (# 279-01).

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Resources for
MACS
®
GMP PepTivator
®
EBV Select

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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®
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®
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