REAlease® CD159a (NKG2A) Complexes, human

REAlease
®
CD159a (NKG2A) Complexes
, human

Clone: REAL283 | Dilution: 1:50
Clone REAL283 is an antibody fragment derived from the full CD159a (NKG2A) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL283 recognizes CD159a, an inhibitory natural killer (NK) cell receptor. CD159a forms heterodimer with CD94 and contains a C-type lectin ectodomain. Inhibitory signal is transmitted by the heterodimer via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and upon ligand engagement, ITIMs are phosphorylated and transmit signal through docking of various tyrosine phosphatases. CD159a/CD94 binds non-classical MHC class I protein, HLA-E. Expression of CD159a is found mainly on NK cells and on subsets of CD8
+
cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

KLRC1, CD159a, NKG2, NKG2A

Technical specifications

  • Antigen: CD159a (NKG2A)
  • Clone: REAL283
  • Isotype control: REAL Control
  • Alternative names of antigen: KLRC1, CD159a, NKG2, NKG2A
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Boyington, J. C. et al. (1999) Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. Immunity 10(1): 75-82
    2. Sullivan, L. C. et al. (2007) The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity 27(6): 900-911
    3. Wolpert, F. et al. (2015) Interferon-β modulates the innate immune response against glioblastoma initiating cells. PLoS One 10(10): e0139603
    4. Veluchamy, J. P. et al. (2017) High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status. Cancer Immunol. Immunother. 66: 51-61
    5. Jacomet, F. et al. (2017)
      The hypothesis of the human iNKT/innate CD8
      +
      T-cell axis applied to cancer: evidence for a deficiency in chronic myeloid leukemia.
      Front Immunol 7: 688
Product options: 9
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 275,00 
for 30
tests
(1)
EUR 140,00 
for 100
tests
(1)
EUR 325,00 
for 30
tests
(1)
EUR 140,00 
for 100
tests
(1)
EUR 325,00 
for 100
tests
(1)
EUR 330,00 
for 100
tests
(1)
EUR 380,00 
for 100
tests
(1)
EUR 380,00 

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