CD98 antibodies, human

CD98 antibodies, human

Clone: REA387 | Dilution: 1:50
Clone REA387 recognizes the human CD98 antigen, a single-pass type II membrane glycoprotein. CD98 is broadly expressed on non-hematopoietic cells and also on peripheral blood lymphocytes, monocytes, and granulocytes. The CD98 heterodimer consists of a 80–85 kDa heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1) that is disulfide-linked with a multi-pass light chain of 40 kDa. The heavy chain binds to the cytoplasmic tails of integrin-β chains and mediates adhesive signals that control cell spreading, survival, and growth. The light chain functions in amino acid transport. Some of the light chains have broad specificity, but the large neutral amino acid transporters LAT-1 and LAT-2 have preference for importing certain essential amino acids, particularly leucine, isoleucine, and arginine (LAT-1), in exchange for glutamine. Through its nutrient function, CD98 can contribute to the survival and growth of many cell types. CD98hc functions in amplifying integrin signaling and in the transport of amino acids. Both of these functions can contribute to cell survival and proliferation.
Additional information: Clone REA387 displays negligible binding to Fc receptors.

Alternative names

SLC3A2, SLC7A5, 4F2hc

Technical specifications

  • Antigen: CD98
  • Clone: REA387
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SLC3A2, SLC7A5, 4F2hc
  • Entrez Gene ID: 6520, 8140
  • Molecular mass of antigen [kDa]: 123
  • Cross-reactivity:
    olive baboon (
    Papio anubis
    chimpanzee (
    Pan troglodytes
  • Distribution of antigen: lymphocytes, monocytes, granulocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Quackenbush, E. et al. (1987) Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. Proc. Natl. Acad. Sci. U.S.A. 84(18): 6526-6530
    2. Cantor, J. M. et al. (2012) CD98 at the crossroads of adaptive immunity and cancer. J. Cell. Sci. 125(6): 1373-1382
    3. Kanai, Y. et al. (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273(37): 23629-23632
Product options: 2

CD98-PE, human

for 30
EUR 113,00 

CD98-PE, human

for 100
EUR 273,00 

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