CD95 (FAS) antibodies, human

CD95 (FAS) antibodies, human

Clone: DX2 | Dilution: 1:50
CD95, also known as FAS or Apo-1, is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FASL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine “fratricide” of neighbouring lymphocytes via mutual CD95 and CD95L expression helps to terminate immune responses, while apoptosis of pro-inflammatory cells via CD95 helps maintain immune privilege in sites such as the eye, where CD95L is found to be expressed in the retina and cornea. Cross-linking of CD95 receptors by DX2 monoclonal antibody has been described to induce apoptosis in certain target cells.

Alternative Names

FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6

Technical specifications

  • Antigen: CD95 (FAS)
  • Clone: DX2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6
  • Entrez Gene ID: 355
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, epithelial cells, fibroblasts, heart, kidney, liver, lung, monocytes, neutrophils, ovary, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, APC-Vio770

Related products

5 products available | view all
Product options: 4

Product information

Size
Order no.
Price

CD95 (FAS)-APC, human

  • DX2
  • 1:50
  • For research use only
for 30
tests
(1)
130-117-813
EUR 111,00 

CD95 (FAS)-APC, human

  • DX2
  • 1:50
  • For research use only
for 100
tests
(1)
130-117-701
EUR 300,00 

CD95 (FAS)-APC-Vio770, human

  • DX2
  • 1:50
  • For research use only
for 30
tests
(1)
130-117-826
EUR 129,00 

CD95 (FAS)-APC-Vio770, human

  • DX2
  • 1:50
  • For research use only
for 100
tests
(1)
130-117-714
EUR 308,00