CD88 (C5AR) antibodies, mouse

CD88 (C5AR) antibodies, mouse

Clone: 20/70 | Dilution: 1:50
Clone 20/70 recognizes the mouse CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Alternative names

C5AR1, C5AR, C5R1, D7Msu1

Technical specifications

  • Antigen: CD88 (C5AR)
  • Clone: 20/70
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: C5AR1, C5AR, C5R1, D7Msu1
  • Entrez Gene ID: 12273
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: granulocytes, neutrophils, monocytes, macrophages, liver, epithelial cells, endothelial cells, mast cells, astrocytes, microglia, fibroblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Gerard, C. et al. (1992) Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J. Immunol. 149(8): 2600-2606
    2. Sadik, C. D. et al. (2012) Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. U.S.A. 109(46): E3177-E3185
    3. Bosmann, M. et al. (2013) The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43(7): 1907-1913
Product options: 1
30 µg in 200 µL (1)
EUR 82,00 

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