CD44v6 antibodies, human

CD44v6 antibodies, human

Clone: REA706 | Dilution: 1:50
Clone REA706 recognizes the CD44v6 antigen. CD44 is the receptor for hyaluronic acid (HA), which plays an important role in cell migration, tumor growth, and progression. CD44 is involved in the modification of the activity of receptors including MET and the ERBB family of tyrosine kinases. CD44 is a marker for many types of cancer stem cells (CSC), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.
Additional information: Clone REA706 displays negligible binding to Fc receptors.

Alternative Names

CDw44, Epican, ECMR-III, PGP-I, CSPG9, EMCR III, HCELL, HUTCH-I, H-CAM

Technical specifications

  • Antigen: CD44v6
  • Clone: REA706
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CDw44, Epican, ECMR-III, PGP-I, CSPG9, EMCR III, HCELL, HUTCH-I, H-CAM
  • Entrez Gene ID: 960
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: hematopoietic cells, fibroblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio770, APC-Vio770, Biotin, pure
  • Selected References

    1. Aruffo, A. et al. (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313
    2. Al-Hajj, M. et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100: 3983-3988
    3. Collins, A. T. et al. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65: 10946-10951
    4. Patrawala, L. et al. (2006)
      Highly purified CD44
      +
      prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.
      Oncogene 25: 1696-1708
    5. Dalerba, P. et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 104: 10158-10163
    6. Wang, L. et al. (2013) Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int. J. Biol. Sci. 9(5): 472-479
Product options: 9
130-111-425

CD44v6-APC, human

for 30
tests
(1)
EUR 115,00 
130-111-238

CD44v6-APC, human

for 100
tests
(1)
EUR 270,00 
130-111-426

CD44v6-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-111-239

CD44v6-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-111-427

CD44v6-APC-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-111-240

CD44v6-APC-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-112-769

CD44v6-Biotin, human

for 30
tests
(1)
EUR 95,00 
130-112-580

CD44v6-Biotin, human

for 100
tests
(1)
EUR 230,00 
130-111-241

CD44v6 pure, human

100 µg in 1 mL
EUR 144,00