CD41a antibodies, human

CD41a antibodies, human

Clone: REA386 | Dilution: 1:11
Clone REA386 recognizes the human CD41a antigen, a calcium-dependent complex of CD41/CD61 (GPIIb/IIIa) expressed on normal platelets and megakaryocytes. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin, and thrombospondin and is required for platelet aggregation and clotting. Mutations of either CD41 or CD61 in humans causes Glanzmann’s thrombasthenia. Notably, CD41 is also the first blood-specific marker during
in vitro
differentiation of embryonic stem cells and is expressed on all hematopoietic stem and progenitor cells in the early embryo. However, CD41 expression is downregulated in midgestation embryos, and it is currently thought that CD41 expression on adult hematopoietic stem cells remains switched off throughout adult life.
Additional information: Clone REA386 displays negligible binding to Fc receptors.

Alternative Names

ITGA2B, BDPLT16, BDPLT2, GP2B, GPIIb

Technical specifications

  • Antigen: CD41a
  • Clone: REA386
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA2B, BDPLT16, BDPLT2, GP2B, GPIIb
  • Entrez Gene ID: 3674
  • Molecular mass of antigen [kDa]: 110
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    , baboon, capuchin monkey
  • Distribution of antigen: hematopoietic stem cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA386
HIP8++
CLB-tromb, 6C9+
Product options: 14

Product information

Size
Order no.
Price

CD41a-FITC, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-611
EUR 65,00 

CD41a-FITC, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-559
EUR 255,00 

CD41a-VioBlue, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-610
EUR 85,00 

CD41a-VioBlue, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-558
EUR 300,00 

CD41a-VioGreen, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-609
EUR 111,00 

CD41a-VioGreen, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-557
EUR 326,00 

CD41a-PE-Vio770, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-614
EUR 111,00 

CD41a-PE-Vio770, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-562
EUR 326,00 

CD41a-APC-Vio770, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-615
EUR 98,00 

CD41a-APC-Vio770, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-563
EUR 313,00 

CD41a-PerCP-Vio700, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-616
EUR 98,00 

CD41a-PerCP-Vio700, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-564
EUR 313,00 

CD41a-Biotin, human

  • REA386
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-608
EUR 65,00 

CD41a-Biotin, human

  • REA386
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-556
EUR 255,00 

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