CD39 antibodies, human

CD39 antibodies, human

Clone: REA739 | Dilution: 1:50
Clone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
Additional information: Clone REA739 displays negligible binding to Fc receptors.

Alternative Names

Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Technical specifications

  • Antigen: CD39
  • Clone: REA739
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80
  • Entrez Gene ID: 953
  • Molecular mass of antigen [kDa]: 58
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, Biotin

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA739
MZ18-23C8++
A1++
TU66++
  • Selected References

    1. Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 153(8): 3574-3583
    2. Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271(51): 33116-33122
    3. Borsellino, G. et al. (2007)
      Expression of ectonucleotidase CD39 by FoxP3
      +
      reg cells: hydrolysis of extracellular ATP and immune suppression.
      Blood 110: 1225-1232
Product options: 14

Product information

Size
Order no.
Price

CD39-VioBright FITC, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-792
EUR 120,00 

CD39-VioBright FITC, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-654
EUR 290,00 

CD39-PE, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-788
EUR 110,00 

CD39-PE, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-650
EUR 265,00 

CD39-APC, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-789
EUR 110,00 

CD39-APC, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-651
EUR 265,00 

CD39-PE-Vio615, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-794
EUR 120,00 

CD39-PE-Vio615, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-656
EUR 290,00 

CD39-PE-Vio770, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-790
EUR 120,00 

CD39-PE-Vio770, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-652
EUR 290,00 

CD39-APC-Vio770, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-791
EUR 120,00 

CD39-APC-Vio770, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-653
EUR 290,00 

CD39-Biotin, human

  • REA739
  • 1:50
  • For research use only
for 30
tests
(1)
130-110-787
EUR 90,00 

CD39-Biotin, human

  • REA739
  • 1:50
  • For research use only
for 100
tests
(1)
130-110-649
EUR 220,00