Clone REA217 recognizes CD298, the β3 subunit isoform of Na+
-ATPase, which is a membrane associated enzyme. Na+
-ATPase transports Na+
by coupling the hydrolysis of ATP to the transport of Na+
. The movement of ions across the plasma membrane generates and maintains the electrochemical gradient required for osmoregulation, transport of molecules and nutrients. Na+
-ATPase consists of large catalytic α subunit and a smaller glycoprotein non-catalytic β subunit, which exists in three known isoforms.