CD270 (HVEM) antibodies, mouse

CD270 (HVEM) antibodies, mouse

Clone: REA275 | Dilution: 1:10
Clone REA275 recognizes the CD270 antigen, a type I transmembrane protein of the TNF-receptor superfamily which is also known as Herpes virus entry mediator (HVEM) or tumor necrosis factor receptor like 2 (TR2). CD270 is expressed in multiple tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, monocytes, neutrophils and dendritic cells. Both human and mouse forms of CD270 can mediate entry of herpes simplex virus-1 and -2 (HSV-1 and HSV-2). CD270 transmits both activating and inhibitory signals; e.g interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells.
Additional information: Clone REA275 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF14, ATAR, HVEA, HVEM, Tnfrs14

Technical specifications

  • Antigen: CD270 (HVEM)
  • Clone: REA275
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF14, ATAR, HVEA, HVEM, Tnfrs14
  • Entrez Gene ID: 230979
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: B cells, T cells, monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected References

    1. Hsu, H. et al. (1997) ATAR, a novel tumor necrosis factor receptor family member, signal through TRAF2 and TRAF5. J. Biol. Chem. 272: 13471-13474
    2. Kwon, B. S. et al. (1997) A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J. Biol. Chem. 272: 14272-14276
    3. Kim, W. K. et al. (2012) Absence of herpes virus entry mediator (HVEM) increases bone mass by attenuating receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. Endocrinology 153(10): 4808-4817
Product options: 6
130-103-410

CD270 (HVEM)-PE, mouse

9 µg in 300 µL (1)
EUR 27,00 
130-102-771

CD270 (HVEM)-PE, mouse

30 µg in 1 mL (1)
EUR 80,00 
130-103-411

CD270 (HVEM)-APC, mouse

9 µg in 300 µL (1)
EUR 44,00 
130-102-772

CD270 (HVEM)-APC, mouse

30 µg in 1 mL (1)
EUR 80,00 
130-103-412

CD270 (HVEM)-PE-Vio770, mouse

9 µg in 300 µL (1)
EUR 44,00 
130-102-773

CD270 (HVEM)-PE-Vio770, mouse

30 µg in 1 mL (1)
EUR 100,00