CD262 antibodies, mouse

CD262 antibodies, mouse

Clone: REA1233 | Dilution: 1:50
Clone REA1233 recognizes the murine CD262 antigen, a protein of the TNF-receptor superfamily, expressed on leukocytes, placenta cells, liver cells and some tumor cells and tumor cell lines (such as NIH-3T3). CD262 is also known as Death receptor 5 (DR5), TRAIL-R2, and TNFRSF10B. CD262 is a receptor for TRAIL, its binding induces apoptosis by activating the NF-κB pathway.
Additional information: Clone REA1233 displays negligible binding to Fc receptors.

Alternative names

TNFRSF10B, DR5, KILLER, Ly98, MK, TRAIL-R2, TRICK2A, TRICK2B, TRICKB

Technical specifications

  • Antigen: CD262
  • Clone: REA1233
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF10B, DR5, KILLER, Ly98, MK, TRAIL-R2, TRICK2A, TRICK2B, TRICKB
  • Entrez Gene ID: 21933
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: cancer cells, liver, placenta, leukocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio770, VioBright 515, PE
  • Selected references

    1. Hayakawa, Y. et al. (2004)
      NK cell TRAIL eliminates immature dendritic cells
      in vivo
      and limits dendritic cell vaccination efficacy.
      J. Immunol. 172(1): 123-129
    2. Sato, K et al. (2005) TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse. J. Immunol. (174): 4025-4033
    3. Takeda, K. et al. (2004) Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J. Exp. Med. 4(199): 437-448
    4. Grisendi, G. et al. (2010) Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. Cancer Res. 70(9): 3718-3729
    5. Iannello, A. et al. (2009) Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells. J. Virol. 83(12): 5999-6010
    6. Shanker, A. et al. (2008) Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J. Natl. Cancer Inst. 100(9): 649-662
Product options: 4
130-124-480

CD262-PE, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-124-481

CD262-APC, mouse

30 µg in 200 µL (1)
EUR 80,00 
30 µg in 200 µL (1)
EUR 100,00 
30 µg in 200 µL (1)
EUR 145,00