CD262 antibodies, human

CD262 antibodies, human

Clone: DJR2-4 | Dilution: 1:11
The DJR2-4 antibody binds to death receptor 5 (DR5), member 10B of the TNF receptor superfamily (TNFRSF10B), also known as CD262, TRAIL-R2/ TRAILR2, TRICK2, KILLER, and ZTNFR9. Binding of TNF-related apoptosis-inducing ligand (TRAIL, TNFSF10, TL2, APO2L, Apo-2L) to DR5 induces apoptosis via the intracellular adaptor molecule FADD/MORT. The DR5 receptor is broadly expressed on many tumors and normal tissues. DR5 expression is upregulated by interferon α, taxotere, and paclitaxel, making DR5
target cells more susceptible to NK cell mediated killing.

Alternative names


Technical specifications

  • Antigen: CD262
  • Clone: DJR2-4
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: TNFRSF10B, DR5, KILLER, TRAIL-R2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
  • Entrez Gene ID: 8795
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: heart, leukocytes, liver, lung, ovary, pancreas, placenta, spleen, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
  • Selected references

    1. Sato, K. et al. (2005) TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse. J. Immunol. 174(7): 4025-4033
    2. Uno, K. et al. (2003) TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells. Blood 101(9): 3658-3667
    3. Walczak, H. et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-5397
    4. LaVallee, T. M. et al. (2003) 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63(2): 468-475
    5. Nimmanapalli, R. et al. (2001) Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels. Cancer Res. 62(2): 759-763
    6. Qiu, Y. et al. (2007) The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells. Cancer Res. 67(10): 4973-4980
    7. Cheent, K. and Khakoo, S. I. (2011) Natural killer cells and hepatitis C: action and reaction. Gut 60(2): 268-278
    8. MacFarlane, M. et al. (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 272(41): 25417-25420
    9. Gajate, C. and Mollinedo, F. (2005) Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. 280(12): 11641-11647
    10. Stolfi, C. et al. (2011) 2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression. Mol. Cancer Ther. 10(10): 1969-1981
    11. Shigeno, M. et al. (2003) Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation. Oncogene 22(11): 1653-1662
Product options: 3

CD262-PE, human

for 100
EUR 273,00 

CD262-APC, human

for 100
EUR 273,00 
for 100
EUR 227,00 

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