CD234 (DARC) antibodies, human

CD234 (DARC) antibodies, human

Clone: REA376 | Dilution: 1:50
Clone REA376 recognizes the human CD234 antigen, a multi-pass membrane protein also known as duffy antigen receptor for chemokines (DARC) or Fy glycoprotein (FY). CD234 is responsible for the duffy blood group system and belongs to a family of silent seven-transmembrane spanning receptors, which do not couple to G-proteins and therefore do not transmit intracellular signals like other G-protein–coupled chemokine-receptors leading to integrin activation or cell motility. It binds to a broad range of inflammatory chemokines of both the CC and the CXC chemokine families, but does not interact with homeostatic chemokines. CD234 is expressed on erythrocytes, cerebellar neurons on postcapillary venule, and capillary endothelial cells in a number of peripheral organs including lymph nodes, the lung, and the kidney. In these organs, endothelial CD234 is specifically expressed in the vascular segment involved in leucocyte extravasation. CD234 was shown to mediate chemokine transcytosis from the basolateral to the luminal side of the endothelium, where the chemokines remain immobilized on the tips of endothelial apical microvilli and enhance leucocyte trafficking
in vivo
.
Additional information: Clone REA376 displays negligible binding to Fc receptors.

Alternative Names

ACKR1, CCBP1, WBCQ1, DARC, Dfy, FY, GPD, GpFy

Technical specifications

  • Antigen: CD234 (DARC)
  • Clone: REA376
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ACKR1, CCBP1, WBCQ1, DARC, Dfy, FY, GPD, GpFy
  • Entrez Gene ID: 2532
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: red blood cells, neurons, lung, lymph node, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
Product options: 2

Product information

Size
Order no.
Price

CD234 (DARC)-APC, human

  • REA376
  • 1:50
  • For research use only
for 30
tests
(1)
130-120-313
EUR 105,00 

CD234 (DARC)-APC, human

  • REA376
  • 1:50
  • For research use only
for 100
tests
(1)
130-120-239
EUR 275,00 

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