CD218a (IL-18Rα) antibodies, mouse

CD218a (IL-18Rα) antibodies, mouse

Clone: REA947 | Dilution: 1:50
Clone REA947 recognizes the mouse CD218a antigen, also known as interleukin-18 receptor alpha (IL-18Rα). CD218a, a member of the immunoglobulin superfamily, is a subunit of the heterodimeric receptor complex of alpha- and beta-chains for the pleiotropic proinflammatory IL-18 cytokine. IL-18 belongs to the IL-1 superfamily and is expressed by monocytes, macrophages, epithelial cells, and keratinocytes. CD218a (IL-18Rα) is found on Tʜ1 cells, subsets of NK cells, and granulocytes. IL-18 plays a role in induction of inflammatory mediators, regulation of the cytotoxic activity of NK and T cells, and differentiation and activation of Tʜ1 and Tʜ2 cells.
Additional information: Clone REA947 displays negligible binding to Fc receptors.

Alternative names

IL-18Ra, IL-18Rα, IL-18R1, IL-18R-1, IL-1Rrp

Technical specifications

  • Antigen: CD218a (IL-18Rα)
  • Clone: REA947
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: IL-18Ra, IL-18Rα, IL-18R1, IL-18R-1, IL-1Rrp
  • Entrez Gene ID: 16182
  • Molecular mass of antigen [kDa]: 60
  • Distribution of antigen: granulocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin, FITC
  • Selected references

    1. Wu, C. et al. (2003) IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J. Immunol. 170(11): 5571-5577
    2. Sergi, B. et al. (2004) Interleukin 18 receptor. J. Biol. Regul. Homeost. Agents 18(1): 55-61
    3. Huang, H. Y. et al. (2010) Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients. Fertil. Steril. 94(1): 33-39
Product options: 9
30 µg in 200 µL (1)
EUR 40,00 
30 µg in 200 µL (1)
EUR 80,00 
150 µg in 1 mL (1)
EUR 230,00 
30 µg in 200 µL (1)
EUR 80,00 
150 µg in 1 mL (1)
EUR 230,00 
30 µg in 200 µL (1)
EUR 100,00 
150 µg in 1 mL (1)
EUR 295,00 
30 µg in 200 µL (1)
EUR 40,00 
150 µg in 1 mL (1)
EUR 120,00 

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