CD21 antibodies, human

CD21 antibodies, human

Clone: HB5 | Dilution: 1:11
Clone HB5 recognizes CD21, a type I membrane glycoprotein. Expression of CD21 in humans is found on B cells, follicular dendritic cells, subsets of epithelial cells, and thymic T cells. The primary function attributed to CD21 has been to amplify the B cell receptor (BCR)–mediated signal transduction in response to antigen recognition. To enhance the BCR mediated activation, CD21 associates with CD19 and CD81 in a B cell–specific signal transduction complex, where interaction of BCR with CR2/CD19 amplifies the signals. In addition, CD21 serves as a receptor for split products of complement protein C3, the gp350/220 viral coat protein of the EBV, and the immunoregulatory protein CD23.

Alternative Names

CR2, C3dR, CR, CVID7, SLEB9

Technical specifications

  • Antigen: CD21
  • Clone: HB5
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: CR2, C3dR, CR, CVID7, SLEB9
  • Cross-reactivity:
    common marmoset (
    Callithrix jacchus
    )
  • Distribution of antigen: B cells, dendritic cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected References

    1. Barrington, R. A. et al. (2005) CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J. Immunol. 175: 2589-2867
    2. Cherukuri, A. et al. (2001) The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. J. Immunol. 167: 163-172
    3. Braun, M. et al. (1998) Human B and T lymphocytes have similar amounts of CD21 mRNA, but differ in surface expression of the CD21 glycoprotein. Int. Immunol. 10: 1197-1202
    4. Roberts, M. L. et al. (1996) Epstein—Barr virus binding to CD21, the virus receptor, activates resting B cells via an intracellular pathway that is linked to B cell infection. Virology 77: 3077-3085
Product options: 16

Product information

Size
Order no.
Price

CD21-FITC, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-667
EUR 90,00 

CD21-FITC, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-754
EUR 220,00 

CD21-PE, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-668
EUR 110,00 

CD21-PE, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-716
EUR 265,00 

CD21-APC, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-661
EUR 110,00 

CD21-APC, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-739
EUR 265,00 

CD21-VioBlue, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-670
EUR 115,00 

CD21-VioBlue, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-715
EUR 275,00 

CD21-PE-Vio770, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-734
EUR 120,00 

CD21-PE-Vio770, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-736
EUR 290,00 

CD21-APC-Vio770, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-663
EUR 120,00 

CD21-APC-Vio770, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-718
EUR 290,00 

CD21-PerCP-Vio700, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-669
EUR 120,00 

CD21-PerCP-Vio700, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-737
EUR 290,00 

CD21-Biotin, human

  • HB5
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-720
EUR 90,00 

CD21-Biotin, human

  • HB5
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-749
EUR 220,00