CD192 (CCR2) antibodies, human

CD192 (CCR2) antibodies, human

Clone: REA624 | Dilution: 1:11
Clone REA624 recognizes the CD192 antigen, a G protein–linked seven transmembrane receptor, which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). Two spliced variants of CD192 (CD192A and CD192B) are expressed on peripheral monocytes and basophils as a result of alternate splicing of a single gene and differ at the C-terminal end. CD192 and its main ligand CCL2 have been implicated in a wide range of immunobiological processes and neuropathologies, including recruitment of monocytes and regulation of bone marrow homeostasis, as well as multiple sclerosis, HIV-associated dementia, Alzheimer’s disease, and neuropathic pain.
Additional information: Clone REA624 displays negligible binding to Fc receptors.

Alternative Names

C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, MCP-1R

Technical specifications

  • Antigen: CD192 (CCR2)
  • Clone: REA624
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, MCP-1R
  • Entrez Gene ID: 1231
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: basophils, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin

Specificity

In order to compare the epitope specificity of REAfinity Clone REA624 with other known clones, a competition assay was performed. 
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA624
REA264++
K03602++
48607++
  • Selected References

    1. Charo, I. F. et al. (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. U.S.A. 91(7): 2752-2756
    2. Wong, L. M. et al. (1997) Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J. Biol. Chem. 272(2): 1038-1045
    3. Henrich, T. J. et al. (2013) HIV-1 entry inhibitors: recent development and clinical use. Curr. Opin. Virol. 3(1): 51-57
Product options: 12
130-109-658

CD192 (CCR2)-VioBright FITC, human

for 30
tests
(1)
EUR 120,00 
130-109-599

CD192 (CCR2)-VioBright FITC, human

for 100
tests
(1)
EUR 290,00 
130-109-654

CD192 (CCR2)-PE, human

for 30
tests
(1)
EUR 110,00 
130-109-595

CD192 (CCR2)-PE, human

for 100
tests
(1)
EUR 265,00 
130-109-655

CD192 (CCR2)-APC, human

for 30
tests
(1)
EUR 110,00 
130-109-596

CD192 (CCR2)-APC, human

for 100
tests
(1)
EUR 265,00 
130-109-656

CD192 (CCR2)-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-109-597

CD192 (CCR2)-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-109-657

CD192 (CCR2)-APC-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-109-598

CD192 (CCR2)-APC-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-109-653

CD192 (CCR2)-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-109-594

CD192 (CCR2)-Biotin, human

for 100
tests
(1)
EUR 220,00