CD179a (VpreB) antibodies, human

CD179a (VpreB) antibodies, human

Clone: HSL96 | Dilution: 1:50
Clone HSL96 recognizes the human CD179a antigen, also known as VpreB protein, which has an incompleted Ig V domain-like structure. In association with CD179b it forms a surrogate light chain. CD179a is exclusively expressed on early pre–B cells and pro–B cells. CD179a forms a molecular complex with the Ig-mu chain on pre–B cells. It seems that this complex plays a critical role in the regulation of Ig gene rearrangements in the early steps of B cell differentiation.

Alternative names

VPreB1, VpreB, IGI, IGVPB

Technical specifications

  • Antigen: CD179a (VpreB)
  • Clone: HSL96
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: VPreB1, VpreB, IGI, IGVPB
  • Entrez Gene ID: 7441
  • Molecular mass of antigen [kDa]: 15
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Tsubata, T. et al. (1990) The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. J. Exp. Med. 172(3): 973-976
    2. Bankovich, A. J. et al. (2007) Structural insight into pre-B cell receptor function. Science 316(5822): 291-294
    3. Guelpa-Fonlupt, V. et al. (1994) The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. Mol. Immunol. 31(14): 1099-1108
Product options: 2
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 270,00 

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