CD16b antibodies, human

CD16b antibodies, human

Clone: REA589 | Dilution: 1:11
Clone REA589 recognizes the human CD16b antigen, a glycosylphosphatidylinositol-anchored protein known as low affinity immunoglobulin gamma Fc region receptor III-B. CD16 is expressed in two different isoforms, FcγRIIIa (CD16a) and FcγRIIIb (CD16b) Fc receptors, that bind to the Fc portion of IgG antibodies which mediates NK cell activating. CD16b is present on polymorphonuclear leukocytes (neutrophils), whereas the transmembrane form CD16a is found on human NK cells, macrophages, and mast cells.
Additional information: Clone REA589 displays negligible binding to Fc receptors.

Alternative Names

FCGR3B, Fc-gamma RIIIb, FCG3, FCGR3, FcR-10, FcRIII, FcRIIIb

Technical specifications

  • Antigen: CD16b
  • Clone: REA589
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCGR3B, Fc-gamma RIIIb, FCG3, FCGR3, FcR-10, FcRIII, FcRIIIb
  • Entrez Gene ID: 2215
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: leukocytes, NK cells, macrophages, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, APC-Vio770, Biotin
  • Selected References

    1. Monti, M. et al. (2017) Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells. PLoS One 12
    2. Peltz, G. A. et al. (1989) Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. Proc. Natl. Acad. Sci. U.S.A. 86(3): 1013-1017
    3. Ravetch, J. V. et al. (1989) Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J. Exp. Med. 170(2): 481-497
    4. Gessner, J. E. et al. (1995) The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. J. Biol. Chem. 270(3): 1350-1361
Product options: 12

Product information

Size
Order no.
Price

CD16b-FITC, human

  • REA589
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-191
EUR 90,00 

CD16b-FITC, human

  • REA589
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-144
EUR 220,00 

CD16b-PE, human

  • REA589
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-192
EUR 110,00 

CD16b-PE, human

  • REA589
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-145
EUR 265,00 

CD16b-APC, human

  • REA589
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-193
EUR 110,00 

CD16b-APC, human

  • REA589
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-146
EUR 265,00 

CD16b-VioBlue, human

  • REA589
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-190
EUR 115,00 

CD16b-VioBlue, human

  • REA589
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-143
EUR 275,00 

CD16b-APC-Vio770, human

  • REA589
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-194
EUR 120,00 

CD16b-APC-Vio770, human

  • REA589
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-147
EUR 290,00 

CD16b-Biotin, human

  • REA589
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-189
EUR 90,00 

CD16b-Biotin, human

  • REA589
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-142
EUR 220,00