CD152 antibodies, human

CD152 antibodies, human

Clone: REA1003 | Dilution: 1:50
Clone REA1003 recognizes the human CD152, an integral membrane protein of the immunoglobin superfamily which is also called CTLA-4. CD152 is a negative regulator of T cell activation. It is transiently expressed on activated CD28
+
T cells and is a ligand for CD80 and CD86. CD4
+
FoxP3
+
regulatory T cells are reported to constitutively express CD152. CD152 may also be detected on B cells when cultured with activated T cells.
Additional information: Clone REA1003 displays negligible binding to Fc receptor.

Alternative names

CTLA4, ALPS5, CD, CELIAC3, CTLA-4, GRD4, GSE, IDDM12

Technical specifications

  • Antigen: CD152
  • Clone: REA1003
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CTLA4, ALPS5, CD, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
  • Entrez Gene ID: 1493
  • Molecular mass of antigen [kDa]: 21
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515, Vio667
  • Selected references

    1. Kuiper, H. M. et al. (1995) Activated T cells can induce high levels of CTLA-4 expression on B cells. J. Immunol. 155(4): 1776-1783
    2. Castan, J. et al. (1997) Accumulation of CTLA-4 expressing T lymphocytes in the germinal centres of human lymphoid tissues. Immunology 90(2): 265-271
    3. Schlotmann, T. et al. (2000) CD alphabeta T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 (CD152) in acute malaria. J. Infect. Dis. 182(1): 367-370
    4. Sansom, D. M. and Walker, L. S. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol. Rev. 212: 131-148
Product options: 10
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
130-116-930

CD152-PE, human

for 30
tests
(1)
EUR 110,00 
130-116-810

CD152-PE, human

for 100
tests
(1)
EUR 265,00 
130-116-931

CD152-APC, human

for 30
tests
(1)
EUR 110,00 
130-116-811

CD152-APC, human

for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 275,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 275,00 

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