CD146 (LSEC) antibodies, mouse

CD146 (LSEC) antibodies, mouse

Clone: REA1064 | Dilution: 1:50
Clone REA1064 recognizes the mouse CD146 antigen, which is expressed on mouse endothelial cells, including liver sinusoidal endothelial cells (LSECs), smooth muscle cells, and the basal membrane. LSECs are microvascular endothelial cells lining the hepatic sinusoidal wall. Their strategic positioning favors a tight interaction with lymphocytes migrating through the liver. They possess a high capacity for antigen uptake and processing. However, in contrast to professional antigen-presenting cells, e.g. dendritic cells, they express only low levels of costimulatory molecules.
Additional information: Clone REA1064 displays negligible binding to Fc receptors.

Alternative Names

MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM

Technical specifications

  • Antigen: CD146 (LSEC)
  • Clone: REA1064
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM
  • Entrez Gene ID: 84004
  • Molecular mass of antigen [kDa]: 69
  • Distribution of antigen: dendritic cells, endothelial cells, epithelial cells, fibroblasts, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioBright 515, Biotin
  • Selected References

    1. Harder, R. et al. (1991) Dissection of murine lymphocyte-endothelial cell interaction mechanisms by SV-40-transformed mouse endothelial cell lines: novel mechanisms mediating basal binding, and alpha 4-integrin-dependent cytokine-induced adhesion. Exp. Cell Res. 197: 259-267
    2. Diehl, L. et al. (2008)
      Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8
      +
      T cell tolerance.
      Hepatology 47: 296-305
Product options: 10

Product information

Size
Order no.
Price

CD146 (LSEC)-FITC, mouse

  • REA1064
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-118-406
EUR 40,00 

CD146 (LSEC)-FITC, mouse

  • REA1064
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-118-252
EUR 120,00 

CD146 (LSEC)-PE, mouse

  • REA1064
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-118-407
EUR 80,00 

CD146 (LSEC)-PE, mouse

  • REA1064
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-118-253
EUR 230,00 

CD146 (LSEC)-APC, mouse

  • REA1064
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-118-408
EUR 80,00 

CD146 (LSEC)-APC, mouse

  • REA1064
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-118-254
EUR 230,00 

CD146 (LSEC)-VioBlue, mouse

  • REA1064
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-118-409
EUR 95,00 

CD146 (LSEC)-VioBlue, mouse

  • REA1064
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-118-255
EUR 275,00 

CD146 (LSEC)-VioBright 515, mouse

  • REA1064
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-118-414
EUR 145,00 

CD146 (LSEC)-Biotin, mouse

  • REA1064
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-118-415
EUR 40,00