CD138 antibodies, mouse

CD138 antibodies, mouse

Clone: REA104 | Dilution: 1:10
CD138, also known as syndecan-1, is a type I integral membrane protein belonging to the syndecan protein family which carries three to five heparan sulfate and chondroitin sulfate chains. CD138 is highly expressed on plasma cells and pre–B cells but not on mature peripheral B cells. It is also expressed on fibroblasts and epithelial cells. The expression of CD138 can be regulated by several cytokines and factors, e.g., thrombin, which is reported to increase the synthesis of CD138 molecules that exhibit high-affinity antithrombin-3 binding.
Additional information: Clone REA104 displays negligible binding to Fc receptors.

Alternative names

SDC1, Sstn, Synd, Synd1, SYN-1

Technical specifications

  • Antigen: CD138
  • Clone: REA104
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: SDC1, Sstn, Synd, Synd1, SYN-1
  • Entrez Gene ID: 20969
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: B cells, breast, endothelial cells, epithelial cells, neurons, plasma cells, smooth muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio615, PE-Vio770, Biotin, PE
  • Selected references

    1. Cizmeci-Smith, G. et al. (1997) Thrombin stimulates Syndecan-1 promotor activity and expression of a form of Syndecan-1 that binds antithrombin III in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 17: 2609-2616
    2. Sanderson, R. D. et al. (1989) B lymphocytes express and lose syndecan at specific stages of differentiation. Cell Regul. 1(1): 27-35
    3. Jalkanen, M. et al. (1985) Heparan sulfate proteoglycans from mouse mammary epithelial cells: localization on the cell surface with a monoclonal antibody. J. Cell Biol. 101(3): 976-984
    4. Saunders, S. et al. (1989) Molecular cloning of syndecan, an integral membrane proteoglycan. J. Cell Biol. 108(4): 1547-1556
    5. Chilosi, M. et al. (1999) CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma cells on routine trephine bone marrow biopsies. Mod. Pathol. 12(12): 1101-1106
Product options: 4
9 µg in 300 µL (1)
EUR 69,00 
30 µg in 1 mL (1)
EUR 103,00 
30 µg in 1 mL (1)
EUR 103,00 
30 µg in 1 mL (1)
EUR 41,00 

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