Clone REA157 recognizes the TRA-1-60 antigen, a neuraminidase-resistant carbohydrate epitope expressed on podocalyxin, which is a transmembrane glycoprotein. Podocalyxin is a member of the CD34-related family of sialomucins and is recognized as a stem cell and tumor marker. TRA-1-60 antigen is expressed on the surface of human embryonic stem cells (ESC), embryonic germ cells (EG), and embryonic carcinoma cells (EC). Expression of TRA-1-60 is lost upon differentiation and thus it can be used to assess the differentiation stage of the cells. TRA-1-60 can be detected in the serum of patients with germ cell tumors which contain an EC component.
Additional information: Clone REA157 displays negligible binding to Fc receptors.
PODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin