Anti-TIM-1 antibodies, human

Clone: REA384 | Dilution: 1:50
Clone REA384 recognizes the human T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). Tim-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated T cells, B cells, natural killer T cells, and dendritic cells. The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity
in vivo
through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. In addition to serving as a receptor for filoviruses, human TIM-1 is reported to serve as a receptor for hepatitis A virus and a variety of flaviviruses, alphaviruses, and arenaviruses.
Additional information: Clone REA384 displays negligible binding to Fc receptors.

Alternative names

CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Technical specifications

  • Antigen: TIM-1
  • Clone: REA384
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1
  • Entrez Gene ID: 26762
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: T cells, B cells, NK cells, dendritic cells, kidney, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
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