Anti-TCRγ/δ antibodies, mouse

Anti-TCRγ/δ antibodies, mouse

Clone: REA633 | Dilution: 1:50
Clone REA633 recognizes the mouse TCRγ/δ antigen. The T cell receptor (TCR) is a heterodimeric glycoprotein associated with the CD3 antigen. It consists of an α and a β chain (TCRα/β) or a γ and a δ chain (TCRγ/δ). The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The γ chain forms either disulfide-linked or non-disulfide-linked heterodimers with the δ-subunit. The γ/δ T cell receptor is present on a subset of T lymphocytes in peripheral blood. TCRγ/δ is involved in the antigen recognition of tumor-associated antigens or bacterial antigens presented by MHC class I molecules.
Additional information: Clone REA633 displays negligible binding to Fc receptors.

Alternative Names

TCRgd

Technical specifications

  • Antigen: TCRγ/δ
  • Clone: REA633
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TCRgd
  • Entrez Gene ID: 110066, 110067
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PerCP-Vio700

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA633
GL3++
UC7-13D5++
  • Selected References

    1. Schmolka, N. et al. (2013) Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat. Immunol. 14(10): 1093-1100
    2. Bonneville, M. et al. (2010) Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol. 10(7): 467-478
    3. Wiest, D. L. (2016) Development of γδ T cells, the special-force soldiers of the immune system. Methods Mol. Biol. 1323: 23-32
Product options: 2

Product information

Size
Order no.
Price

Anti-TCRγ/δ-PerCP-Vio700, mouse

  • REA633
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-117-777
EUR 98,00 

Anti-TCRγ/δ-PerCP-Vio700, mouse

  • REA633
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-117-665
EUR 274,00