Anti-Podoplanin antibodies, human

Anti-Podoplanin antibodies, human

Clone: REA446
Clone REA446 recognizes the human podoplanin antigen, a 38–44 kDa mucin-type transmembrane protein which is also known as E11, GP38, OTS8, PA2.26, T1A, or aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis, and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen four days postnatally. In adults, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis.
Additional information: Clone REA446 displays negligible binding to Fc receptors.

Alternative names

PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A

Technical specifications

  • Antigen: Podoplanin
  • Clone: REA446
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A
  • Entrez Gene ID: 10630
  • Molecular mass of antigen [kDa]: 14
  • Distribution of antigen: brain, heart, kidney, lung, osteoblasts, spleen, endothelial cells, dendritic cells, lymph node, epithelial cells, other
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1
100 µg in 100 µL
EUR 164,00