Anti-PLC-γ2 antibodies, human

Anti-PLC-γ2 antibodies, human

Clone: REA488 | Dilution: 1:11
Clone REA488 recognizes the human phosphoinositide phospholipase C-γ-2 (PLC-γ2) antigen regardless of phosphorylation status. PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell–antigen receptors) that are linked to the activation of non-receptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells.
Additional information: Clone REA488 displays negligible binding to Fc receptors.

Alternative names

PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2

Technical specifications

  • Antigen: PLC-γ2
  • Clone: REA488
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
  • Entrez Gene ID: 5336
  • Molecular mass of antigen [kDa]: 148
  • Cross-reactivity: mouse
  • Distribution of antigen: B cells, hematopoietic stem cells, leukocytes, monocytes, macrophages, NK cells, platelets, lymphocytes, T cells, T helper cells, thymocytes, NKT cells, basophils, eosinophils, mast cells, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Ohta, S. et al. (1988) Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. FEBS Lett. 242(1): 31-35
    2. Hikida, M. et al. (2009) PLC-gamma2 is essential for formation and maintenance of memory B cells. J. Exp. Med. 206(3): 681-689
    3. Feng, L. et al. (2012) The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem 54: 463-469
Product options: 6
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 

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